Saturday, 16th February 31st Lorne Cancer Conference 2019

• Pediatric medulloblastoma:  Molecular Pathways and Pre-Clinical Trials - Martine Roussel
• Melanin pigment and melanoma heterogeneity - Gamze Kuser Abali
• Bowel cancer functional genomics and personalised medicine - Susi Woods
• Interconversion between tumourigenic and differentiated states in acute myeloid leukaemia - Ethan P Oxley
• Human stem cell models for pediatric cancers - William Weiss

• Treat the cancer soil: Turn foes to friends - Erwei Song
• Landscape of the Breast Cancer Microenvironment at Single Cell Resolution - Sunny Wu
• ROCK educates cancer-associated fibroblasts via secretion of Creld2 to create a tumour-promoting microenvironment - Sarah T Boyle
• A Wrinkle in TiME: how the aging microenvironment governs tumor progression - Ashani Weeraratna

• Enzymatic DNA repair enables high quality library preparation and accurate sequencing from highly damaged FFPE DNA samples - Margaret Heider

• Non-genomic mechanisms of therapeutic resistance in cancer - Mark Dawson
• DNA Hypermethylation Encroachment at CpG Island Borders in Cancer.   - Clare Stirzaker
• BCL11A cooperates with SOX2 to drive lung squamous cell carcinoma through epigenetic regulators - Kyren Lazarus

17:45 - Ashley Dunn Introductio

• Understanding and exploiting p53 mutation in cancer - Scott Lowe

After Dinner Speaker: Leonie Walsh

Controlling your Career Pathway

Career choices and career pathways have become more complex in recent years. There are many and diverse trends which may impact both current career choices and your ultimate career pathway with most of these influences being out of your control. A diverse range of examples that come to mind include:

• The increase in the development and application of technology increasing automation of roles
• Increasing global competition for workforce skills in areas of shortage
• Increase in the retirement age resulting in Boomers, Generation X and Millennials for the first time simultaneously competing for jobs.
• Federal Government spending on science and research falling well below the OECD average
• Higher job turnover and lower expectations for employment security, benefits, retirement and pensions
• Increase in focus on STEM education, particularly for girls and women
• Greater focus on the importance of gender equity and diversity more broadly
• Introduction of quotas and other measures to improve gender balance and participation in activities
• Increased research into the genetic and neuroscience influence on capabilities such as leadership
• Changing academic pathways including life-long learning and micro credentials

Career success no longer relies on traditional linear career pathways and working your way up through long term employment. There is still the opportunity to focus careers in specific areas of interest however there is an increasing focus today on breadth of skills, experiences and connections, supplemented by timely and relevant academic qualifications, to allow flexibility for non-linear career pathways and dynamic changes in the job market.

This presentation will identify socio-economic trends that have the potential to impact the 21^st century workforce and provide several examples of successful careers, with both linear and non-linear pathways. The aim is to explore the core and common skills that can help to navigate some of the barriers to career success, including gender influenced barriers, and provide several insights into navigating the 21^st century workforce.