During advanced stages of cancer, roughly 50-80% of the patients experience rapid weight loss resulting in about one-third of cancer-related deaths. Cancer associated cachexia is defined as a multifactorial metabolic syndrome characterized by the rapid loss of skeletal muscle mass with or without the loss of fat mass. Pro-inflammatory and pro-cachectic factors are significantly upregulated in cachexia patients and these are thought to be the main players in mediating proteolysis and lipolysis in the skeletal muscles and adipose tissues, respectively. Though it is speculated that cancer cells themselves induce the cachexia, it is unclear as how this process is regulated. Extracellular vesicles (EVs) including exosomes and microvesicles are implicated in cell-cell communication, immune response, tissue repair, epigenetic regulation and in various diseases including cancer. It has been reported that exosomes, which are about 30-150 nm in diameter, have shown to regulate cancer progression, metastasis, organotropism and chemoresistance. In recent times, the role of exosomes in regulating cancer cachexia is beginning to unravel and we hypothesize that tumour derived exosomes specifically induce proteolysis in muscle and lipolysis in adipose tissue. The objective of the project is to understand the role of tumour derived exosomes in promoting catabolism in distally located skeletal muscles and adipose tissue. In line with the high mortality rate in cancer patients, addressing cachexia is critical to manage cancer therapy.